List of Champions of the 1921 U.S. National Championships (now known as the US Open):
Bill Tilden defeated Wallace F. Johnson 6-1 6-3 6-1
Molla Bjurstedt Mallory defeated Mary Browne 4-6, 6-4, 6-2
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| Preceded by 1920 U.S. National Championships |
U.S. National Championships | Succeeded by 1922 U.S. National Championships |
| Preceded by 1921 Wimbledon Championships |
Grand Slams | Succeeded by 1922 Australasian Championships |